Prof. Komatsu's team released the world leading paper in Materials Advances and also appeared on the front cover.
Biomolecular Chemistry, Komatsu Lab. lead by Professor Dr. Teruyuki Komatsu is one of the most active and professional lab. in Chuo University.
The paper on “Catalase–albumin cluster incorporating protoporphyrin IX: an O2 generating photosensitizer for enhanced photodynamic therapy” was published in Materials Advances (an international, gold open access journal, publishing high-quality research across the breadth of materials science) and appeared on the front cover.
Photodynamic therapy (PDT) is a non-surgical cancer treatment using a light source such as an LED or laser. To confer stronger O2 generation ability to the sensitizer for cancer treatment, Prof. Komatsu exploited a catalase (Cat) which is the most powerful H2O2 dismutation enzyme in nature. For this study, Prof. Komatsu’s team have demonstrated the synthesis, structure, and enzymatic activity of the Cat-HSA5 cluster (HSA: human serum albumin). Moreover, the photophysical properties and PDT activity of Cat-HSA5 incorporating protoporphyrin IX (PP) [Cat-(HSA-PP)5] have been characterized. The results indicate that his approach can create a new class of dual-functional hemoprotein-based medicines for advanced PDT.
Paper published in Mater. Adv. 2022, 3, 6451-6457.
Author: Taiga Yamada (PhD Student in Komatsu Lab.) , Maho Katsumi (MSC Student in Komatsu Lab.), Yuka Yagisawa, Masato Ichihara and Teruyuki Komatsu
You can find more of his research and collaboration here.