- 後楽園キャンパス 3号館 3907号室
Prof. Damien Arraign （Australia，Curtin university）
Prof. Damien Arraign （Australia，Curtin university）がJASIS 2019に参加されるために来日される機会に，最近その応用が注目されている液液界面を利用した電気分析手法の原理と応用について，基礎となる液液界面でのイオン・物質移動の熱力学的考察とinterface between two immiscible electrolyte solutions (ITIES)）での電気分析に関してご講演をお願いしました．是非ご参集ください．
題目 ：Exploring electroanalytical chemistry at liquid-liquid interfaces
Electrochemistry at liquid-liquid (oil-water) interfaces, or at the interface between two immiscible electrolyte solutions (ITIES), offers a simple strategy for chemical and biochemical sensing. Ion detection based on dynamic ion transfer electrochemistry at the ITIES relies on simple or facilitated (e.g. with an ionophore) transfer of ions , with sensitivity and selectivity achieved via the measured current and the applied potential, respectively. This seminar will introduce the concepts of electrochemistry at the ITIES and focus on two key areas of development: electroanalysis at nanoscale ITIES and electrochemical detection of bio(macro)molecules.
In order to improve the sensitivity of sensing based on electrochemistry at the ITIES, miniaturised (i.e. micro- or nano-) interfaces have been examined . The preparation of arrays of nanoITIES within the nanopores of a perforated membrane enables an amplification of the electrochemical signal. Consequently, the current signal will depend on the array design, in particular the inter-pore spacing which should be optimised for independent mass transport to the interfaces located there. The detection of biological macromolecules at the ITIES provides a simple strategy for the detection of target analytes, such as proteins, in a label-free manner. This detection is based on protein-anion complexation at the interface and adsorption of the complex . Exploiting the adsorption enables detection of nanomolar concentrations of proteins, while harnessing the enzymatic activity of specific biomarkers has allowed detection of sub-picomolar concentrations.
 D.W.M. Arrigan, G. Herzog, Theory of electrochemistry at miniaturised interfaces between two immiscible electrolyte solutions, Curr. Op. Electrochem., 2017, 1, 66.
 D.W.M. Arrigan, M.J. Hackett, R.L. Mancera, Electrochemistry of proteins at the interface between two immiscible electrolyte solutions, Curr. Op. Electrochem. 2018, 12, 27.