講演題目：Heavy Metal Complexes with Thiol-containing Molecules of Biological Interest
The toxicity of heavy metals such as lead, mercury and cadmium in biological systems is frequently attributed to their strong preference for thiol groups (-SH), which can inhibit the activity of cellular enzymes. Cysteine is a thiol containing amino acid, and is an important building block for proteins. The tri-peptide glutathione (g-Glutamyl-Cysteine-Glycine), the most abundant cellular thiol in the body, is important for protecting organisms against heavy metal ions. Penicillamine (3,3’-dimethyl cysteine) and N-acetylcysteine are clinically used for heavy metal detoxification.
During this lecture, the results of our investigations will be presented on Hg(II) and Pb(II) complex formation in aqueous solution with small thiol-containing molecules of biological interest such as cysteine, penicillamine, N-acetylcysteine and glutathione, using a combination of different techniques, including extended X-ray absorption fine structure (EXAFS) spectroscopy, multinuclear NMR (199Hg, 207Pb) and Raman spectroscopy.