Prof. Michael J. Krische講演会開催

日程: ２０１３年６月５日（水） 16:20 - 18:00
場所: 後楽園キャンパス６号館　４階６４０９号室

日程: ２０１３年６月５日（水） 16:20 - 18:00

場所: 後楽園キャンパス６号館　４階６４０９号室

内容: Prof. Michael J. Krische （Department of Chemistry and Biochemistry, University of Texas at Austin，USA）が来日される機会に，最近その応用が注目されている還元的カップリング反応について，基礎となる有機金属錯体触媒の性質と水素移動反応に関してご講演をお願いしました．是非ご参集ください．

題目　　　： Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation
講演者：\tProf. Michael J. Krische
（Department of Chemistry and Biochemistry, University of Texas at Austin，USA）
日時　　　：　２０１３年６月５日（水） 16:20 - 18:00
場所　　　：　中央大学後楽園キャンパス６号館　４階６４０９号室

アブストラクト：
Reactions that form carbon-carbon bonds are of fundamental to the endeavor of chemical synthesis. The largest volume application of homogenous metal catalyzed C-C coupling is alkene hydroformylation, which may be viewed as the prototypical C-C bond forming hydrogenation. Our laboratory is engaged in the first systematic efforts to develop C-C bond forming hydrogenations beyond hydroformylation-processes wherein two or more reactants are hydrogenated to form a single, more complex product. Using cationic rhodium and iridium catalysts, we have found that diverse π-unsaturated reactants reductively couple to carbonyl compounds and imines under hydrogenation conditions, offering a byproduct-free alternative to stoichiometric organometallics in a range of classical C=X (X = O, NR) addition processes. This concept is extended further via “C-C bond forming transfer hydrogenation”. In such processes, the exchange of hydrogen between alcohols and unsaturated reactants serves to generate aldehyde-organometal pairs that combine to give products of carbonyl addition or hydrohydroxyalkylation. Direct alcohol CH-functionalization in this manner is again byproduct-free, and avoids discrete redox manipulations often required to convert alcohols to aldehydes.

世話人：　福澤信一